The World Health Organisation has called on countries to be more aggressive and step up control measures as the number of coronavirus cases continue to soar.
With case numbers worldwide more than doubling in the past six weeks, Uzbekistan on Friday returned to lockdown and Hong Kong said schools would close from Monday after the city recorded "exponential growth" in locally transmitted infections.
WHO chief Tedros Adhanom Ghebreyesus called on countries to adopt an aggressive approach, highlighting Italy, Spain, South Korea and India's biggest slum to show it was possible to stop the spread, no matter how bad the outbreak.
The health agency's comments came as US President Donald Trump was forced to cancel an election rally in New Hampshire, citing an approaching storm.
Trump has pushed to hold large gatherings against health advice as epidemiologists warn of the dangers posed by the virus moving through the air in crowded and confined spaces.
On a visit to Florida on Friday, Trump hit out at Beijing over the pandemic.
"(The) relationship with China has been severely damaged. They could have stopped the plague.... They didn´t stop it," he told reporters.
The virus has killed at least 556,140 people worldwide since it emerged in China last December.
More than 12.3 million cases have been registered in 196 countries and territories, triggering massive economic damage.
The United States, the country worst hit by the illness, reported almost 64,000 new cases Friday and the death toll now stands at just under 134,000, according to Johns Hopkins University.
Brazil, the second-hardest hit, surpassed 70,000 deaths and reported 45,000 new infections, the health ministry said.
In Uzbekistan, citizens were from Friday facing lockdown restrictions again that were originally imposed in March but lifted gradually over the past two months.
The Central Asian country's return to confinement followed a decision by Australia to lock down its second-biggest city Melbourne from Thursday.
A police officer manning a checkpoint on the outskirts of the former Soviet republic's capital said only drivers with "a good reason" to enter Tashkent — such as delivering food or other vital supplies — could pass.
Restaurants, gyms, swimming pools and non-food markets have all shut their doors until at least August 1.
Private transport within cities will be limited to morning and early evening journeys and essential purposes such as travelling to work and purchasing food or medicine.
In Hong Kong, the spike marks a setback for the city after daily life had largely returned to normal with restaurants and bars resuming regular business and cultural attractions reopening.
Despite being right next to mainland China where the virus first emerged, the city had managed to quash local transmission in recent months.
But new clusters have started to emerge since Tuesday, including at an elderly care home that reported at least 32 cases and a housing estate with 11.